T cell-specific gamma genes in C57BL/10 mice. Sequence and expression of new constant and variable region genes.

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T cell-specific gamma genes in C57BL/10 mice. Sequence and expression of new constant and variable region genes

The T cell-specific gamma genes in C57BL/10 (B10) mice have been analyzed. Based on the cDNA sequences of these genes from antigen-specific MHC-restricted cytotoxic T cells, we found that the repertoire of these genes is not as limited as previously postulated (8). T cells from the B10 mice express an identical copy of V gamma J gamma C gamma (V gamma 10.8A-JC gamma 10.5) transcript previously ...

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Interleukin 7-induced expression of specific T cell receptor gamma variable region genes in murine fetal liver cultures

We previously reported that culture of murine fetal liver (FL) cells with interleukin 7 (IL-7) results in expression of high levels of T cell receptor (TCR) gamma transcripts by a population of cells expressing Thy-1 and Pgp-1, suggesting that IL-7 promotes the growth and/or differentiation of pre-T cells. We demonstrate herein that culture of FL cells for 7 d with IL-7 caused the rearrangement...

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Ordered rearrangement of variable region genes of the T cell receptor gamma locus correlates with transcription of the unrearranged genes

T cell receptor V gamma genes rearrange to the J gamma 1 gene segment in a highly ordered fashion during development. We demonstrate a striking correlation between the pattern of expression of unrearranged V gamma genes and the timing of their rearrangement. Thus, the increases in V gamma 2 rearrangements, and decreases in V gamma 3 and V gamma 4 rearrangements observed during development are p...

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oligoclonal expression of t-cell receptor beta variable genes in normal human endometrium

in spite of their key role in various immunological processes occurring in the endometrium, t cells- especially + subtype- residing in this mucosal tissue, have not been extensively explored. we present here the profile of expressed genes for variable region of chain of t cell receptor (tcr) in normal endometrium as compared to peripheral blood. samples from endometrium were taken from norm...

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We report the nucleotide sequence of a gene encoding a human immunoglobulin C gamma 2 region. Comparison with the previously determined C gamma 4 sequence reveals that these two genes share extensive (approximately 95%) homology in the three CH domain exons and adjacent noncoding regions. In contrast, hinge exons have diverged to a much greater degree, implying that natural selection has favore...

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 1986

ISSN: 0022-1007,1540-9538

DOI: 10.1084/jem.163.5.1203